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Proceedings Paper

A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging
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Paper Abstract

Both optical coherence tomography (OCT) and selective plane illumination microscopy (SPIM) are frequently used in mouse embryonic research for high-resolution three-dimensional imaging. However, each of these imaging methods provide a unique and independent advantage: SPIM provides morpho-functional information through immunofluorescence and OCT provides a method for whole-embryo 3D imaging. In this study, we have combined rotational imaging OCT and SPIM into a single, dual-modality device to image E9.5 mouse embryos. The results demonstrate that the dual-modality setup is able to provide both anatomical and functional information simultaneously for more comprehensive tissue characterization.

Paper Details

Date Published: 8 February 2017
PDF: 4 pages
Proc. SPIE 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System, 100430L (8 February 2017); doi: 10.1117/12.2252677
Show Author Affiliations
Chen Wu, Univ. of Houston (United States)
Shihao Ran, Univ. of Houston (United States)
Henry Le, Baylor College of Medicine (United States)
Manmohan Singh, Univ. of Houston (United States)
Irina V. Larina, Baylor College of Medicine (United States)
David Mayerich, Univ. of Houston (United States)
Mary E. Dickinson, Baylor College of Medicine (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)


Published in SPIE Proceedings Vol. 10043:
Diagnosis and Treatment of Diseases in the Breast and Reproductive System
Melissa C. Skala; Paul J. Campagnola, Editor(s)

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