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Proceedings Paper

Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma
Author(s): Konstantin S. Yashin; Elena B. Kiseleva; Ekaterina V. Gubarkova; Lev A. Matveev; Maria M. Karabut; Vadim V. Elagin; Marina A. Sirotkina; Igor A. Medyanik; L. Ya. Kravets; Natalia D. Gladkova
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Paper Abstract

In the case of infiltrative brain tumors the surgeon faces difficulties in determining their boundaries to achieve total resection. The aim of the investigation was to evaluate the performance of multimodal OCT (MM OCT) for differential diagnostics of normal brain tissue and glioma using an experimental model of glioblastoma. The spectral domain OCT device that was used for the study provides simultaneously two modes: cross-polarization and microangiographic OCT. The comparative analysis of the both OCT modalities images from tumorous and normal brain tissue areas concurrently with histologic correlation shows certain difference between when accordingly to morphological and microvascular tissue features.

Paper Details

Date Published: 8 February 2017
PDF: 7 pages
Proc. SPIE 10050, Clinical and Translational Neurophotonics, 100500Z (8 February 2017); doi: 10.1117/12.2252286
Show Author Affiliations
Konstantin S. Yashin, Privolzhsky Federal Research Medical Ctr. (Russian Federation)
Nizhny Novgorod State Medical Academy (Russian Federation)
Elena B. Kiseleva, Nizhny Novgorod State Medical Academy (Russian Federation)
Ekaterina V. Gubarkova, Nizhny Novgorod State Medical Academy (Russian Federation)
Lev A. Matveev, Institute of Applied Physics (Russian Federation)
Maria M. Karabut, Nizhny Novgorod State Medical Academy (Russian Federation)
Vadim V. Elagin, Nizhny Novgorod State Medical Academy (Russian Federation)
Marina A. Sirotkina, Nizhny Novgorod State Medical Academy (Russian Federation)
Igor A. Medyanik, Privolzhsky Federal Research Medical Ctr. (Russian Federation)
L. Ya. Kravets, Privolzhsky Federal Research Medical Ctr. (Russian Federation)
Natalia D. Gladkova, Nizhny Novgorod State Medical Academy (Russian Federation)


Published in SPIE Proceedings Vol. 10050:
Clinical and Translational Neurophotonics
Steen J. Madsen; Victor X. D. Yang, Editor(s)

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