Share Email Print
cover

Proceedings Paper

3D wide field-of-view Gabor-domain optical coherence microscopy advancing real-time in-vivo imaging and metrology
Author(s): Cristina Canavesi; Andrea Cogliati; Adam Hayes; Patrice Tankam; Anand Santhanam; Jannick P. Rolland
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Real-time volumetric high-definition wide-field-of-view in-vivo cellular imaging requires micron-scale resolution in 3D. Compactness of the handheld device and distortion-free images with cellular resolution are also critically required for onsite use in clinical applications. By integrating a custom liquid lens-based microscope and a dual-axis MEMS scanner in a compact handheld probe, Gabor-domain optical coherence microscopy (GD-OCM) breaks the lateral resolution limit of optical coherence tomography through depth, overcoming the tradeoff between numerical aperture and depth of focus, enabling advances in biotechnology. Furthermore, distortion-free imaging with no post-processing is achieved with a compact, lightweight handheld MEMS scanner that obtained a 12-fold reduction in volume and 17-fold reduction in weight over a previous dual-mirror galvanometer-based scanner. Approaching the holy grail of medical imaging – noninvasive real-time imaging with histologic resolution – GD-OCM demonstrates invariant resolution of 2 μm throughout a volume of 1 x 1 x 0.6 mm3, acquired and visualized in less than 2 minutes with parallel processing on graphics processing units. Results on the metrology of manufactured materials and imaging of human tissue with GD-OCM are presented.

Paper Details

Date Published: 17 February 2017
PDF: 6 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100530Z (17 February 2017); doi: 10.1117/12.2252187
Show Author Affiliations
Cristina Canavesi, LighTopTech Corp. (United States)
Andrea Cogliati, LighTopTech Corp. (United States)
Univ. of Rochester (United States)
Adam Hayes, The Institute of Optics, Univ. of Rochester (United States)
Patrice Tankam, The Institute of Optics, Univ. of Rochester (United States)
Anand Santhanam, Univ. of California, Los Angeles (United States)
Jannick P. Rolland, LighTopTech Corp. (United States)
The Institute of Optics, Univ. of Rochester (United States)


Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top