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Proceedings Paper

Multimodal OCT for assessment of vasculature-targeted PDT success
Author(s): Marina A. Sirotkina; Ekaterina V. Gubarkova; Elena B. Kiseleva; Vladimir Y. Zaitsev; Mikhail Y. Kirillin; Alexander A. Sovetsky; Alexander L. Matveyev; Lev A. Matveev; Sergey S. Kuznetsov; Elena V. Zagaynova; Alex Vitkin; Natalia D. Gladkova
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Paper Abstract

The main goal of the study was a vasculature targeted PDT. A new approach named M-mode-like OCT (MML OCT) was applied to monitor early response to PDT. Due to the chosen filtering parameters (96 Hz filter threshold), this approach visualizes only vessels with flowing blood. Without flowing blood even filled vessels are not visualized because flow-less blood causes speckle variations with significantly lower frequencies (<50 Hz corresponding to speckle decorrelation time for stationary blood). This feature allows us to detect thrombosis of blood vessels, the results of MML OCT and histological examination being perfectly coinciding. The advantages of MML OCT such as a simple and fast process of obtaining microvasculature images and label-free nature of the visualization makes this method perspective in routine clinical monitoring of antitumor therapies.

Paper Details

Date Published: 8 February 2017
PDF: 7 pages
Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 100470Q (8 February 2017); doi: 10.1117/12.2251914
Show Author Affiliations
Marina A. Sirotkina, Nizhny Novgorod State Medical Academy (Russian Federation)
Ekaterina V. Gubarkova, Nizhny Novgorod State Medical Academy (Russian Federation)
Elena B. Kiseleva, Nizhny Novgorod State Medical Academy (Russian Federation)
Vladimir Y. Zaitsev, Nizhny Novgorod State Medical Academy (Russian Federation)
Institute of Applied Physics (Russian Federation)
Mikhail Y. Kirillin, Institute of Applied Physics (Russian Federation)
Alexander A. Sovetsky, Institute of Applied Physics (Russian Federation)
Alexander L. Matveyev, Nizhny Novgorod State Medical Academy (Russian Federation)
Institute of Applied Physics (Russian Federation)
Lev A. Matveev, Nizhny Novgorod State Medical Academy (Russian Federation)
Institute of Applied Physics (Russian Federation)
Sergey S. Kuznetsov, Nizhny Novgorod State Medical Academy (Russian Federation)
Elena V. Zagaynova, Nizhny Novgorod State Medical Academy (Russian Federation)
Alex Vitkin, Nizhny Novgorod State Medical Academy (Russian Federation)
Institute of Applied Physics (Russian Federation)
Univ. of Toronto (Canada)
Natalia D. Gladkova, Nizhny Novgorod State Medical Academy (Russian Federation)


Published in SPIE Proceedings Vol. 10047:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
David H. Kessel; Tayyaba Hasan, Editor(s)

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