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Proceedings Paper

Assessing corneal viscoelasticity after crosslinking at different IOP by noncontact OCE and a modified Lamb wave model
Author(s): Zhaolong Han; Jiasong Li; Manmohan Singh; Chen Wu; Chih-hao Liu; Raksha Raghunathan; Salavat R. Aglyamov; Srilatha Vantipalli; Michael D. Twa; Kirill V. Larin
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Paper Abstract

UV-A/riboflavin collagen cross-linking (UV-CXL) is a clinical treatment for keratoconus that stiffens mechanically degraded corneal tissue. On the other hand, the intraocular pressure (IOP) can also affect the measured cornea elasticity. However, the combined effects of CXL at different IOPs on the corneal biomechanical properties are not well understood. In this work, the feasibility of assessing the viscoelasticity of the porcine cornea before and after CXL at various IOPs was investigated by using a noncontact method of optical coherence elastography (OCE) and a modified Lamb wave model. The modified wave model was first verified by comparison with finite element modeling, and then utilized to quantify the viscoelasticity of porcine corneas in the whole eye-globe configuration before and after CXL treatment at various IOPs. The results show that the elasticity of the cornea increased after CXL and that corneal stiffness was linear as a function of IOP. At IOPs of 15, 20, 25, and 30 mmHg, the relative increase in Young’s modulus after CXL was ~109%, ~86%, ~64%, and ~79%, respectively, while the shear viscosity decreased by ~86%, ~84%, ~83%, and ~81%. The modified Lamb wave model and OCE show promise for quantifying corneal viscoelasticity, which could provide a basis for customized CXL therapies and accurate disease detection.

Paper Details

Date Published: 8 February 2017
PDF: 6 pages
Proc. SPIE 10045, Ophthalmic Technologies XXVII, 1004502 (8 February 2017); doi: 10.1117/12.2251784
Show Author Affiliations
Zhaolong Han, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Chih-hao Liu, Univ. of Houston (United States)
Raksha Raghunathan, Univ. of Houston (United States)
Salavat R. Aglyamov, The Univ. of Texas at Austin (United States)
Srilatha Vantipalli, Univ. of Houston (United States)
Michael D. Twa, The Univ. of Alabama at Birmingham (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)


Published in SPIE Proceedings Vol. 10045:
Ophthalmic Technologies XXVII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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