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Proceedings Paper

A fast atlas-guided high density diffuse optical tomography system for brain imaging
Author(s): Xianjin Dai; Tao Zhang; Hao Yang; Huabei Jiang
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Paper Abstract

Near infrared spectroscopy (NIRS) is an emerging functional brain imaging tool capable of assessing cerebral concentrations of oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) during brain activation noninvasively. As an extension of NIRS, diffuse optical tomography (DOT) not only shares the merits of providing continuous readings of cerebral oxygenation, but also has the ability to provide spatial resolution in the millimeter scale. Based on the scattering and absorption properties of nonionizing near-infrared light in biological tissue, DOT has been successfully applied in the imaging of breast tumors, osteoarthritis and cortex activations. Here, we present a state-of-art fast high density DOT system suitable for brain imaging. It can achieve up to a 21 Hz sampling rate for a full set of two-wavelength data for 3-D DOT brain image reconstruction. The system was validated using tissue-mimicking brain-model phantom. Then, experiments on healthy subjects were conducted to demonstrate the capability of the system.

Paper Details

Date Published: 17 February 2017
PDF: 8 pages
Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 100591I (17 February 2017); doi: 10.1117/12.2251534
Show Author Affiliations
Xianjin Dai, Univ. of Florida (United States)
Tao Zhang, Univ. of Florida (United States)
Hao Yang, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)


Published in SPIE Proceedings Vol. 10059:
Optical Tomography and Spectroscopy of Tissue XII
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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