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Proceedings Paper

Baseline oxygen saturation comparison between pathologic complete responders and extensive residual cancer cases in response to neoadjuvant chemotherapy
Author(s): Mirella L. Altoe; Jacqueline E. Gunther; Emerson Lim; Hyun Keol Kim; Jessica Campbell; Hanina Hibshoosh; Katherine Crew; Kevin Kalinsky; Dawn L. Hershman; Andreas H. Hielscher
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Paper Abstract

In this retrospective cohort study, we examine the hypothesis that baseline oxygen saturation (SO2%) in contralateral normal tissue can be a quantitative measurement for predicting tumor response to neoadjuvant chemotherapy (NAC). Using our dynamic custom-built dual breast dynamic diffuse optical tomography (DOT) imager, we reconstructed SO2% measurement concentration for 12 stage II or III breast cancer patients. Six patients achieved pCR (RCB-0) and the other half had extensive residual disease (RCB-III). Baseline SO2% in contralateral normal tissue was statistically significantly higher in RCB-III subjects than in pCR (p = 0.025). From ROC analyses, baseline SO2% in contralateral normal breast tissue was able to discriminate pCR from RCB-III patients (AUC 0.889) with sensitivity and specificity of 83%.

Paper Details

Date Published: 17 February 2017
PDF: 6 pages
Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 100590Q (17 February 2017); doi: 10.1117/12.2251452
Show Author Affiliations
Mirella L. Altoe, Columbia Univ. (United States)
Jacqueline E. Gunther, Columbia Univ. (United States)
Emerson Lim, Columbia Univ. (United States)
Hyun Keol Kim, Columbia Univ. (United States)
Jessica Campbell, Herbert Irving Comprehensive Cancer Ctr. (United States)
Hanina Hibshoosh, Columbia Univ. (United States)
Katherine Crew, Columbia Univ. (United States)
Kevin Kalinsky, Columbia Univ. (United States)
Dawn L. Hershman, Columbia Univ. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)


Published in SPIE Proceedings Vol. 10059:
Optical Tomography and Spectroscopy of Tissue XII
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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