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Proceedings Paper

Simultaneous two-photon imaging of cerebral oxygenation and capillary blood flow in atherosclerotic mice
Author(s): Xuecong Lu; Baoqiang Li; Mohammad Moeini; Frédéric Lesage
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Paper Abstract

Gradual changes in brain microvasculature and cerebral capillary blood flow occurring with atherosclerosis may significantly contribute to cognition decline due to their role in brain tissue oxygenation. However, previous stud- ies of the relationship between cerebral capillary blood flow and brain tissue oxygenation are limited. This study aimed to investigate vascular and concomitant changes in brain tissue pO2 with atherosclerosis. Experiments in young healthy C57B1/6 mice (n=6 , WT), young atherosclerotic mice (n=6 , ATX Y) and old atherosclerotic mice (n=6 , ATX O) were performed imaging on the left sensory-motor cortex at resting state under urethane (1.5 g/kg) anesthesia using two-photon fluorescence microscopy. The results showed that pO2 around capillaries, correlated with red blood cell (RBC) flux, increased with atherosclerosis.

Paper Details

Date Published: 8 February 2017
PDF: 6 pages
Proc. SPIE 10051, Neural Imaging and Sensing, 100510O (8 February 2017); doi: 10.1117/12.2251437
Show Author Affiliations
Xuecong Lu, École Polytechnique de Montréal (Canada)
Montreal Heart Institute (Canada)
Baoqiang Li, École Polytechnique de Montréal (Canada)
Harvard Medical School (United States)
Mohammad Moeini, École Polytechnique de Montréal (Canada)
Montreal Heart Institute (Canada)
Frédéric Lesage, École Polytechnique de Montréal (Canada)
Montreal Heart Institute (Canada)


Published in SPIE Proceedings Vol. 10051:
Neural Imaging and Sensing
Qingming Luo; Jun Ding, Editor(s)

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