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Proceedings Paper

Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment
Author(s): Ygal Rotenstreich; Daniel Ben-Ner; Inbal Sharvit-Ginon; Ramit Ravona-Springer; Michal Beeri; Ifat Sher
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Paper Abstract

The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.

Paper Details

Date Published: 23 March 2017
PDF: 1 pages
Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100451Z (23 March 2017); doi: 10.1117/12.2251428
Show Author Affiliations
Ygal Rotenstreich, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Tel Aviv Univ. (Israel)
Daniel Ben-Ner, Chaim Sheba Medical Ctr (Israel)
Tel Aviv Univ. (Israel)
Inbal Sharvit-Ginon, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Bar Ilan Univ. (Israel)
Ramit Ravona-Springer, Tel Aviv Univ. (Israel)
The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Michal Beeri, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Ifat Sher, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)


Published in SPIE Proceedings Vol. 10045:
Ophthalmic Technologies XXVII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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