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Proceedings Paper

In situ monitoring of collagen fibers in human skin using a photonic-crystal-fiber-coupled, hand-held, second-harmonic-generation microscope
Author(s): K. Atsuta; Y. Ogura; E. Hase; T. Minamikawa; T. Yasui
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Paper Abstract

Second-harmonic-generation (SHG) microscopy is a powerful tool for in situ monitoring of collagen fibers in human skin. However, its practical use is still limited in the dermatological field due to the bulky and complicated setup. In this paper, we constructed a photonic-crystal-fiber-coupled, hand-held SHG microscope for in situ monitoring of collagen fibers in human skin. Fiber delivery of femtosecond pulse light was achieved by a large-mode-area photonic-crystal-fiber whereas the compact SHG microscopy setup was enclosed into a lens tube system. The combination of PCF with the lens tube system largely enhances the flexibility of measurement sites in the human skin.

Paper Details

Date Published: 21 February 2017
PDF: 6 pages
Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100692B (21 February 2017); doi: 10.1117/12.2251321
Show Author Affiliations
K. Atsuta, The Univ. of Tokushima (Japan)
Y. Ogura, The Univ. of Tokushima (Japan)
E. Hase, The Univ. of Tokushima (Japan)
T. Minamikawa, The Univ. of Tokushima (Japan)
T. Yasui, The Univ. of Tokushima (Japan)


Published in SPIE Proceedings Vol. 10069:
Multiphoton Microscopy in the Biomedical Sciences XVII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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