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Proceedings Paper

In vivo photoacoustic mouse eye imaging of healing after chemical injury and automated eyeball surface estimation based on a random sample consensus algorithm
Author(s): Seungwan Jeon; Hyun Beom Song; Jaewoo Kim; Byung Joo Lee; Jeong Hun Kim; Chulhong Kim
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Paper Abstract

Ocular chemical damage may induce limbal vessel ischemia and neovascularization, but the pathophysiology of the disease is not completely known. To observe changes in blood vessels after alkaline burn, we monitored the anterior segment and choroidal vasculature using a photoacoustic microscope (OR-PAM). We were able to observe not only the iris blood vessels but also the choroidal vessels under the sclera, which were difficult to be observed with conventional photographs. After alkali burning, we observed neovascularization and limbal ischemia and successfully tracked changes in vasculature during the 7-day healing process. We also used the RANdom SAmple Consensus (RANSAC) method to segment the abnormally generated blood vessels in the cornea by detecting the eyeball surface and successfully visualize the distance from each PA signal to the center of the eye. We believe that photoacoustic imaging has an important potential to reveal the pathophysiology of limb ischemia and neovascularization.

Paper Details

Date Published: 3 March 2017
PDF: 5 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100640D (3 March 2017); doi: 10.1117/12.2251289
Show Author Affiliations
Seungwan Jeon, Pohang Univ. of Science and Technology (Korea, Republic of)
Hyun Beom Song, Seoul National Univ. College of Medicine (Korea, Republic of)
Jaewoo Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Byung Joo Lee, Seoul National Univ. College of Medicine (Korea, Republic of)
Jeong Hun Kim, Seoul National Univ. College of Medicine (Korea, Republic of)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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