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Proceedings Paper

Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy
Author(s): Karla A. Montejo; Joseph Chue-Sang; Yuqiang Bai; Susan Stoff; Nola Holness; Mariacarla Gonzalez; Jefferson Gomes; Amir Gandjbakhche; Viktor V. Chernomordik; Jessica C. Ramella-Roman
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Paper Abstract

Preterm birth (PTB) presents a serious medical heath concern in both economically developed and developing nations, with incidence rate from 15%-11% respectively. Changes in cervical collagen bundle orientation and distribution may prove to be a predictor of PTB. Polarization imaging is an effective means to measure optical anisotropy in birefringent biological tissue such as those rich in collagen. Non-invasive, full-field Mueller Matrix polarimetry (MMP) imaging methodologies, optical coherence tomography (OCT), and second harmonic generation (SHG) microscopy were used to assess cervical collagen content and structure in non-pregnant cervices. In vivo studies using a Mueller Matrix colposcope are underway. Further studies of cervical collagen orientation throughout pregnancy are needed to understand if Mueller matrix polarimetry can effectively identify at-risk conditions for PTB.

Paper Details

Date Published: 2 March 2017
PDF: 10 pages
Proc. SPIE 10043, Diagnosis and Treatment of Diseases in the Breast and Reproductive System, 1004303 (2 March 2017); doi: 10.1117/12.2250987
Show Author Affiliations
Karla A. Montejo, Florida International Univ. (United States)
Joseph Chue-Sang, Florida International Univ. (United States)
Yuqiang Bai, Florida International Univ. (United States)
Susan Stoff, Florida International Univ. (United States)
Nola Holness, Florida International Univ. (United States)
Mariacarla Gonzalez, Florida International Univ. (United States)
Jefferson Gomes, Florida International Univ. (United States)
Amir Gandjbakhche, Eunice Kennedy Shriver National Institute of Child Health and Human Development (United States)
Viktor V. Chernomordik, Eunice Kennedy Shriver National Institute of Child Health and Human Development (United States)
Jessica C. Ramella-Roman, Florida International Univ. (United States)


Published in SPIE Proceedings Vol. 10043:
Diagnosis and Treatment of Diseases in the Breast and Reproductive System
Melissa C. Skala; Paul J. Campagnola, Editor(s)

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