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Proceedings Paper

3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico
Author(s): Emiyu Ogawa; Yuko Uno; Keishi Ohtani; Sachio Maehara; Kentaro Imai; Shotaro Ono; Jitsuo Usuda; Tsunenori Arai
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Paper Abstract

We studied a 3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico. Drug distribution might change after intravenous injection from plasma to interstitial space and then into myocardial cells. We have developed a new cardiac ablation using photosensitization reaction with laser irradiation shortly after talaporfin sodium injection. We think that the major cell-killing factor in our cardiac ablation would be an oxidation by singlet oxygen produced in the interstitial space in myocardium with laser irradiation shortly after the photosensitizer administration. So that the talaporfin sodium concentration change in time in the interstitial space should be investigated. We constructed the pharmacokinetics dynamic model composed by 3-compartments, that is, plasma, interstitial space, and cell. We measured talaporfin sodium fluorescence time change in human skin by our developed fluorescence measurement system in vivo. Using the measured concentration data in plasma and skin in human, we verified the calculation accuracy of our in silico model. We compared the simulated transition tendency of talaporfin sodium concentration from interstitial space to cells in our in silico model with the reported uptake tendency using cultured myocardial cell. We identified the transition coefficients between plasma, interstitial space, and cell compartment, and metabolization coefficient from plasma by the fitting with measured data.

Paper Details

Date Published: 8 February 2017
PDF: 4 pages
Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 100470Y (8 February 2017); doi: 10.1117/12.2250716
Show Author Affiliations
Emiyu Ogawa, Keio Univ. (Japan)
Yuko Uno, Keio Univ. (Japan)
Keishi Ohtani, Tokyo Medical Univ. (Japan)
Sachio Maehara, Tokyo Medical Univ. (Japan)
Kentaro Imai, Tokyo Medical Univ. (Japan)
Shotaro Ono, Tokyo Medical Univ. (Japan)
Jitsuo Usuda, Nippon Medical School (Japan)
Tsunenori Arai, Keio Univ. (Japan)


Published in SPIE Proceedings Vol. 10047:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
David H. Kessel; Tayyaba Hasan, Editor(s)

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