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Proceedings Paper

Cherenkov-excited luminescence sheet imaging (CELSI) tomographic reconstruction
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Paper Abstract

A tomographic reconstruction algorithm for Cherenkov-excited luminescence scanned imaging (CELSI) is proposed and demonstrated for the first time, to reconstruct distributions of luminescent source. Coupled continuous wave (CW) diffusion equations are used to model luminescent photon propagation in biological tissues. The CELSI reconstruction was achieved by minimizing the difference between measured and computed data based on Tikhonov regularization technique. The feasibility and effectiveness of the algorithm were tested with numerical simulations on noisy data. In addition, comparisons between conventional diffuse optical fluorescence tomography (DOFT) and CELSI were also performed. Contrast-detail analysis was also used to evaluate the imaging performance of CELSI.

Paper Details

Date Published: 8 February 2017
PDF: 6 pages
Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 1004912 (8 February 2017); doi: 10.1117/12.2250670
Show Author Affiliations
Jinchao Feng, Thayer School of Engineering at Dartmouth (United States)
Beijing Univ. of Technology (China)
Petr Bruza, Thayer School of Engineering at Dartmouth (United States)
Hamid Dehghani, The Univ. of Birmingham (United Kingdom)
Scott C. Davis, Thayer School of Engineering at Dartmouth (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)


Published in SPIE Proceedings Vol. 10049:
Molecular-Guided Surgery: Molecules, Devices, and Applications III
Brian W. Pogue; Sylvain Gioux, Editor(s)

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