Share Email Print
cover

Proceedings Paper

Temperature sensing of adipose tissue heating with the luminescent upconversion nanoparticles as nanothermometer: in vitro study
Author(s): I. Yu. Yanina; E. K. Volkova; A. M. Zaharevich; J. G. Konyukhova; V. I. Kochubey; V. V. Tuchin
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

The luminescence spectra of upconversion nanoparticles (UCNPs) imbedded in fat tissue were measured in a wide temperature range, from room to human body and further to hyperthermic temperatures. The two types of synthesized UCNP [NaYF4:Yb3+, Er3+] specimens, namely, powdered as-is and embedded into polymer film, were used. The results show that the luminescence of UCNPs placed under the adipose tissue layer is reasonably good sensitive to temperature change and reflects phase transitions of lipids in tissue cells. The most likely, multiple phase transitions are associated with the different components of fat cells such as phospholipids of cell membrane and lipids of fat droplets. In the course of fat cell heating, lipids of fat droplet first transit from a crystalline form to a liquid crystal form and then to a liquid form, which is characterized by much less scattering. The phase transitions of lipids were observed as the changes of the slope of the temperature dependence of UCNP luminescence intensity. The obtained results confirm a high sensitivity of the luminescent UCNPs to the temperature variations within tissues and show a strong potential for providing a controllable tissue thermolysis.

Paper Details

Date Published: 3 March 2017
PDF: 10 pages
Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100631A (3 March 2017); doi: 10.1117/12.2250587
Show Author Affiliations
I. Yu. Yanina, Saratov National Research State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
E. K. Volkova, Saratov National Research State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
A. M. Zaharevich, Saratov National Research State Univ. (Russian Federation)
J. G. Konyukhova, Saratov National Research State Univ. (Russian Federation)
V. I. Kochubey, Saratov National Research State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
V. V. Tuchin, Saratov National Research State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)


Published in SPIE Proceedings Vol. 10063:
Dynamics and Fluctuations in Biomedical Photonics XIV
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top