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Proceedings Paper

LoC-SERS toward clinical application: quantification of antibiotics in human urine samples
Author(s): I. J. Hidi; M. Jahn; K. Weber; M. W. Pletz; T. W. Bocklitz; D. Cialla-May; J. Popp
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Paper Abstract

The determination of the concentration of xenobiotics in biological matrix followed by the change of the prescribing procedure plays a major role in the transition from general to personalized medicine. For this contribution, human urine samples collected from healthy volunteers and from patients having urinary tract infection were used as biological matrix to assess the potential and limitation of LoC-SERS to detected levofloxacin and nitroxoline. The determination of both antibiotics at clinically relevant concentrations, 1.38 mM ± 0.68 mM for levofloxacin and 10-40 µM for nitroxoline, will be presented. For quantification purposes the standard addition method is combined with LoC-SERS.

Paper Details

Date Published: 17 April 2017
PDF: 1 pages
Proc. SPIE 10080, Plasmonics in Biology and Medicine XIV, 100800N (17 April 2017); doi: 10.1117/12.2250533
Show Author Affiliations
I. J. Hidi, Friedrich-Schiller-Univ. Jena (Germany)
Leibniz-Institut für Photonische Technologien e.V. (Germany)
M. Jahn, Friedrich-Schiller-Univ. Jena (Germany)
Leibniz-Institut für Photonische Technologien e.V. (Germany)
K. Weber, Friedrich-Schiller-Univ. Jena (Germany)
Leibniz-Institut für Photonische Technologien e.V. (Germany)
M. W. Pletz, Friedrich-Schiller-Univ. Jena (Germany)
Leibniz-Institut für Photonische Technologien e.V. (Germany)
T. W. Bocklitz, Friedrich-Schiller-Univ. Jena (Germany)
Leibniz-Institut für Photonische Technologien e.V. (Germany)
D. Cialla-May, Friedrich-Schiller-Univ. Jena (Germany)
Leibniz-Institut für Photonische Technologien e.V. (Germany)
J. Popp, Friedrich-Schiller-Univ. Jena (Germany)
Leibniz-Institut für Photonische Technologien e.V. (Germany)


Published in SPIE Proceedings Vol. 10080:
Plasmonics in Biology and Medicine XIV
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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