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Combined synthetic aperture focusing technique and three-dimensional deconvolution for resolution enhancement in photoacoustic microscopy
Author(s): De Cai; Zhongfei Li; Yao Li; Zhendong Guo; Sung-Liang Chen
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Paper Abstract

Acoustic-resolution photoacoustic microscopy (ARPAM) is a promising tool for deep imaging of biological tissues. Synthetic aperture focusing technique (SAFT) can improve the degraded lateral resolution in the out-of-focus region of ARPAM when using a high numerical aperture acoustic transducer. We previously reported a three-dimensional (3D) deconvolution technique to improve both lateral and axial resolutions in the focus region of ARPAM. In this work, we extended resolution enhancement of ARPAM to the out-of-focus region based on two dimensional SAFT combined with the 3D deconvolution (SAFT+Deconv). In both the focus and out-of-focus regions, depth-independent lateral and axial resolution after SAFT ensures a depth-independent point spread function for 3D deconvolution algorithm. In an extended depth of focus (DOF) of ∼2 mm, SAFT+Deconv ARPAM improves the −6 dB lateral resolutions from 65–700 μm to 20–29 μm, and the −6 dB axial resolutions from 35–42 μm to 12–19 μm. The signal-to-noise ratio is also increased by 6–30 dB. The enhanced resolution in extended DOF by SAFT+Deconv ARPAM may enable important applications in biomedical photoacoustic imaging.

Paper Details

Date Published: 3 March 2017
PDF: 7 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006427 (3 March 2017); doi: 10.1117/12.2250456
Show Author Affiliations
De Cai, Shanghai Jiao Tong Univ. (China)
Zhongfei Li, Shanghai Jiao Tong Univ. (China)
Yao Li, Shanghai Jiao Tong Univ. (China)
Zhendong Guo, Shanghai Jiao Tong Univ. (China)
Sung-Liang Chen, Shanghai Jiao Tong Univ. (China)


Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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