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Proceedings Paper

Quantified elasticity mapping of ocular tissue using acoustic radiation force optical coherence elastography (Conference Presentation)
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Paper Abstract

Age-related macular degeneration and keratoconus are two ocular diseases occurring in the posterior and anterior eye, respectively. In both conditions, the mechanical elasticity of the respective tissues changes during the early onset of disease. It is necessary to detect these differences and treat the diseases in their early stages to provide proper treatment. Acoustic radiation force optical coherence elastography is a method of elasticity mapping using confocal ultrasound waves for excitation and Doppler optical coherence tomography for detection. We report on an ARF-OCE system that uses modulated compression wave based excitation signals, and detects the spatial and frequency responses of the tissue. First, all components of the system is synchronized and triggered such that the signal is consistent between frames. Next, phantom studies are performed to validate and calibrate the relationship between the resonance frequency and the Young’s modulus. Then the frequency responses of the anterior and posterior eye are detected for porcine and rabbit eyes, and the results correlated to the elasticity. Finally, spatial elastograms are obtained for a porcine retina. Layer segmentation and analysis is performed and correlated to the histology of the retina, where five distinct layers are recognized. The elasticities of the tissue layers will be quantified according to the mean thickness and displacement response for the locations on the retina. This study is a stepping stone to future in-vivo animal studies, where the elastic modulus of the ocular tissue can be quantified and mapped out accordingly.

Paper Details

Date Published: 19 April 2017
PDF: 1 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005321 (19 April 2017); doi: 10.1117/12.2250439
Show Author Affiliations
Yueqiao Qu, Beckman Laser Institute and Medical Clinic (United States)
Youmin He, Beckman Laser Institute and Medical Clinic (United States)
Yi Zhang, USC Roski Eye Institute (United States)
Teng Ma, Resource Ctr. for Medical Ultrasonic Transducer Technology, The Univ. of Southern California (United States)
Jiang Zhu, Beckman Laser Institute and Medical Clinic (United States)
Yusi Miao, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Cuixia Dai, Beckman Laser Institute and Medical Clinic (United States)
Ronald Silverman, Columbia Univ. Medical Ctr. (United States)
Mark S. Humayun, USC Roski Eye Institute (United States)
Qifa Zhou, Resource Ctr. for Medical Ultrasonic Transducer Technology, The Univ. of Southern California (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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