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Proceedings Paper

Analysis of anhydrous glucose and human serum assisted by Raman spectroscopy
Author(s): Naara González; H. H. Cerecedo-Núñez; P. Padilla-Sosa; Aaron Flores; Manuel May; Miguel Basurto; Gabriela Alcántara; Omar Muñiz
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Paper Abstract

Raman spectroscopy has been considered like a potentially important clinical tool for real-time diagnosis of disease and evaluation of living tissue, whit the proposal to development noninvasive glucose measurements in a near future, with lower power than other reported studies, in this work are reported experimental tests made with a excitation source of semiconductor laser of 785 nm and 35 mW power.

Measurements were made to different glucose concentrations, with variation from 50 mg/dL to 6000 mg/dL. For this, three intervals with different ranges of concentration were analyzed, these tests were put into plastic sampling cells, making incise the beam vertically on sample. In the same way measurements to serum human are reported, for healthy volunteers had 12 hours fasting and non-fasting conditions, with it's corresponding values of glucose taken through a conventional glucometer.

Freeze-dried human serum was poured on object-holder, in the case of human serum reconstitute, it was used container in which were previously kept samples. Nine spectra per test were obtained and subsequently average was calculated, the spectra were studied in a range of 500 to 1700 cm-1. This work explores the intensity variation of the bands of glucose in 1065 cm-1 and 1127 cm-1 as a function of glucose concentration. In the obtained results, there observes a behavior with positive slope in both substances, interrelation being observed between the measurements, being promissory for non-invasive measurement.

Paper Details

Date Published: 28 February 2017
PDF: 6 pages
Proc. SPIE 10058, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVII, 100580J (28 February 2017); doi: 10.1117/12.2249876
Show Author Affiliations
Naara González, Univ. Veracruzana (Mexico)
H. H. Cerecedo-Núñez, Univ. Veracruzana (Mexico)
P. Padilla-Sosa, Univ. Veracruzana (Mexico)
Aaron Flores, Univ. Autónoma del Carmen (Mexico)
Manuel May, Univ. Autónoma del Carmen (Mexico)
Miguel Basurto, Univ. Autónoma del Estado de Morelos (Mexico)
Gabriela Alcántara, Univ. Veracruzana (Mexico)
Omar Muñiz, Univ. Veracruzana (Mexico)


Published in SPIE Proceedings Vol. 10058:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVII
Israel Gannot, Editor(s)

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