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Proceedings Paper

Development of time-resolved reflectance diffuse optical tomography for breast cancer monitoring
Author(s): Kenji Yoshimoto; Etsuko Ohmae; Daisuke Yamashita; Hiroaki Suzuki; Shu Homma; Tetsuya Mimura; Hiroko Wada; Toshihiko Suzuki; Nobuko Yoshizawa; Hatsuko Nasu; Hiroyuki Ogura; Harumi Sakahara; Yutaka Yamashita; Yukio Ueda
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Paper Abstract

We developed a time-resolved reflectance diffuse optical tomography (RDOT) system to measure tumor responses to chemotherapy in breast cancer patients at the bedside. This system irradiates the breast with a three-wavelength pulsed laser (760, 800, and 830 nm) through a source fiber specified by an optical switch. The light collected by detector fibers is guided to a detector unit consisting of variable attenuators and photomultiplier tubes. Thirteen irradiation and 12 detection points were set to a measurement area of 50 × 50 mm for a hand-held probe. The data acquisition time required to obtain the temporal profiles within the measurement area is about 2 minutes. The RDOT system generates topographic and tomographic images of tissue properties such as hemoglobin concentration and tissue oxygen saturation using two imaging methods. Topographic images are obtained from the optical properties determined for each source-detector pair using a curve-fitting method based on the photon diffusion theory, while tomographic images are reconstructed using an iterative image reconstruction method. In an experiment using a tissue-like solid phantom, a tumor-like cylindrical target (15 mm diameter, 15 mm high) embedded in a breast tissue-like background medium was successfully reconstructed. Preliminary clinical measurements indicated that the tumor in a breast cancer patient was detected as a region of high hemoglobin concentration. In addition, the total hemoglobin concentration decreased during chemotherapy. These results demonstrate the potential of RDOT for evaluating the effectiveness of chemotherapy in patients with breast cancer.

Paper Details

Date Published: 17 February 2017
PDF: 10 pages
Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 100590M (17 February 2017); doi: 10.1117/12.2249597
Show Author Affiliations
Kenji Yoshimoto, Hamamatsu Photonics K.K. (Japan)
Etsuko Ohmae, Hamamatsu Photonics K.K. (Japan)
Daisuke Yamashita, Hamamatsu Photonics K.K. (Japan)
Hiroaki Suzuki, Hamamatsu Photonics K.K. (Japan)
Shu Homma, Hamamatsu Photonics K.K. (Japan)
Tetsuya Mimura, Hamamatsu Photonics K.K. (Japan)
Hiroko Wada, Hamamatsu Photonics K.K. (Japan)
Toshihiko Suzuki, Hamamatsu Photonics K.K. (Japan)
Nobuko Yoshizawa, Hamamatsu Univ. School of Medicine (Japan)
Hatsuko Nasu, Hamamatsu Univ. School of Medicine (Japan)
Hiroyuki Ogura, Hamamatsu Univ. School of Medicine (Japan)
Harumi Sakahara, Hamamatsu Univ. School of Medicine (Japan)
Yutaka Yamashita, Hamamatsu Photonics K.K. (Japan)
Yukio Ueda, Hamamatsu Photonics K.K. (Japan)


Published in SPIE Proceedings Vol. 10059:
Optical Tomography and Spectroscopy of Tissue XII
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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