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Proceedings Paper

Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers for bioimaging and sensing applications
Author(s): Xiaoyu Cheng; Benjamin F. P. McVey; Andrew B. Robinson; Guillaume Longatte; Peter B. O’Mara; Vincent T. G. Tan; Pall Thordarson; Richard D. Tilley; Katharina Gaus; J. Justin Gooding
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Paper Abstract

In this paper we present recent advances in Förster resonance energy transfer (FRET) sensing and bioimaging using nontoxic silicon quantum dots. (SiQDs) In our work, we prepare SiQDs-dye conjugates, with SiQDs serving as the donor which are covalently attached to organic dye acceptors via self-assembled monolayer linkers. Enzymatic cleavage of the peptide leads to changes in FRET response which was monitored using fluorescence lifetime imaging microscopy (FLIM-FRET). The combination of interfacial design and optical imaging presented in this work opens new opportunities for bio-applications using nontoxic silicon quantum dots.

Paper Details

Date Published: 22 February 2017
PDF: 10 pages
Proc. SPIE 10078, Colloidal Nanoparticles for Biomedical Applications XII, 100780O (22 February 2017); doi: 10.1117/12.2249592
Show Author Affiliations
Xiaoyu Cheng, The Univ. of New South Wales (Australia)
Benjamin F. P. McVey, The Univ. of New South Wales (Australia)
Andrew B. Robinson, The Univ. of New South Wales (Australia)
Guillaume Longatte, The Univ. of New South Wales (Australia)
Peter B. O’Mara, The Univ. of New South Wales (Australia)
Vincent T. G. Tan, The Univ. of New South Wales (Australia)
Pall Thordarson, The Univ. of New South Wales (Australia)
Richard D. Tilley, The Univ. of New South Wales (Australia)
Katharina Gaus, The Univ. of New South Wales (Australia)
J. Justin Gooding, The Univ. of New South Wales (Australia)


Published in SPIE Proceedings Vol. 10078:
Colloidal Nanoparticles for Biomedical Applications XII
Marek Osiński; Wolfgang J. Parak; Xing-Jie Liang, Editor(s)

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