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Proceedings Paper

Evaluation of a multi-layer diffuse reflectance spectroscopy system using optical phantoms
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Paper Abstract

A fiber probe-based device for assessing microcirculatory parameters, especially red blood cell (RBC) tissue fraction, their oxygen saturation and speed resolved perfusion, has been evaluated using state-of-the-art multi-layer tissue simulating phantoms. The device comprises both diffuse reflectance spectroscopy (DRS) at two source-detector separations (0.4 and 1.2 mm) and laser Doppler flowmetry (LDF) and use an inverse Monte Carlo method for identifying the parameters of a multi-layered tissue model. First, model parameters affecting scattering, absorption and geometrical parameters are fitted to measured DRS spectra, then speed parameters are fitted to LDF spectra. In this paper, the accuracy of the spectral parameters is evaluated. The measured spectral shapes at the two source-detector separations were in good agreement with forward calculated spectral shapes. In conclusion, the multi-layer skin model based on spectral features of the included chromophores, can reliably estimate the tissue fraction of RBC, its oxygen saturation and the reduced scattering coefficient spectrum of the tissue. Furthermore, it was concluded that some freedom in the relative intensity difference between the two DRS channels is necessary in order to compensate for non-modeled surface structure effects.

Paper Details

Date Published: 14 March 2017
PDF: 11 pages
Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560G (14 March 2017); doi: 10.1117/12.2249562
Show Author Affiliations
Ingemar Fredriksson, Linköping Univ. (Sweden)
Perimed AB (Sweden)
Rolf B. Saager, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Tomas Strömberg, Linköping Univ. (Sweden)
Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 10056:
Design and Quality for Biomedical Technologies X
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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