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Proceedings Paper

Multimodal optical imaging database from tumour brain human tissue: endogenous fluorescence from glioma, metastasis and control tissues
Author(s): Fanny Poulon; Ali Ibrahim; Marc Zanello; Johan Pallud; Pascale Varlet; Fatima Malouki; Georges Abi Lahoud; Bertrand Devaux; Darine Abi Haidar
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Paper Abstract

Eliminating time-consuming process of conventional biopsy is a practical improvement, as well as increasing the accuracy of tissue diagnoses and patient comfort. We addressed these needs by developing a multimodal nonlinear endomicroscope that allows real-time optical biopsies during surgical procedure. It will provide immediate information for diagnostic use without removal of tissue and will assist the choice of the optimal surgical strategy. This instrument will combine several means of contrast: non-linear fluorescence, second harmonic generation signal, reflectance, fluorescence lifetime and spectral analysis. Multimodality is crucial for reliable and comprehensive analysis of tissue. Parallel to the instrumental development, we currently improve our understanding of the endogeneous fluorescence signal with the different modalities that will be implemented in the stated. This endeavor will allow to create a database on the optical signature of the diseased and control brain tissues. This proceeding will present the preliminary results of this database on three types of tissues: cortex, metastasis and glioblastoma.

Paper Details

Date Published: 2 March 2017
PDF: 5 pages
Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100692M (2 March 2017); doi: 10.1117/12.2249498
Show Author Affiliations
Fanny Poulon, IMNC Lab., Paris-Saclay Univ., CNRS (France)
Ali Ibrahim, IMNC Lab., Paris-Saclay Univ., CNRS (France)
Marc Zanello, Ctr. Hospitalier Sainte-Anne (France)
Johan Pallud, Ctr. Hospitalier Sainte-Anne (France)
Univ. Paris Descartes (France)
Pascale Varlet, Univ. Paris Descartes (France)
IMABRAIN, INSERM (France)
Ctr. Hospitalier Sainte-Anne (France)
Fatima Malouki, IMNC Lab., Paris-Saclay Univ., CNRS (France)
Georges Abi Lahoud, Ctr. Hospitalier Sainte-Anne (France)
Univ. Paris Descartes (France)
Bertrand Devaux, Ctr. Hospitalier Sainte-Anne (France)
Univ. Paris Descartes (France)
Darine Abi Haidar, IMNC Lab., Paris-Saclay Univ., CNRS (France)
Paris Diderot Univ. (France)


Published in SPIE Proceedings Vol. 10069:
Multiphoton Microscopy in the Biomedical Sciences XVII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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