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Proceedings Paper

Coagulation monitoring based on blood elastic measurement using optical coherence tomography
Author(s): Xiangqun Xu; Jiang Zhu; Zhongping Chen
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Paper Abstract

Blood coagulation monitoring is important to diagnose hematological diseases and cardiovascular diseases and to predict the risk of bleeding and excessive clotting. In this study, we developed a system to dynamically monitor blood coagulation and quantitatively determine the coagulation function by blood elastic measurement. When blood forms a clot from a liquid, ultrasonic force induces a shear wave, which is detected by optical coherence tomography (OCT). The coagulation of porcine whole blood recalcified by calcium chloride is assessed using the metrics of reaction time, clot formation kinetics and maximum shear modulus. The OCE system can noninvasively monitor the blood coagulation and quantitatively determine the coagulation function.

Paper Details

Date Published: 17 February 2017
PDF: 5 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005332 (17 February 2017); doi: 10.1117/12.2248450
Show Author Affiliations
Xiangqun Xu, Zhejiang Sci-Tech Univ. (China)
Beckman Laser Institute (United States)
Jiang Zhu, Beckman Laser Institute (United States)
Zhongping Chen, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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