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Proceedings Paper

Optoelectronic method for determining platinum in biological products
Author(s): Simona Radu; Mihai Ionică; Radu Alexandru Macovei; Genica Caragea; Mărgărita Forje; Iulia Grecu; Marian Vlădescu; Oana Viscol
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Paper Abstract

Of all platinum metals, platinum has the most uses and it’s the most abundant and most easily to be processed. Its use in auto catalysts results in environmental contamination of crowded cities and high-traffic roads. In medicine, Pt is used as a cytostatic drug. In order to study the degree of contamination of the population with Pt or the correctness of treatment with Pt, it has been developed a method for its determination from urine or blood samples with a system Graphite Furnance - Atomic Absorption Spectrometer, (GF-AAS) Varian. There are presented the methods of sampling processing for blood or urine that followed the digest of the organic matrix. In the determination of the operating parameters for the system GF-AAS, was aimed the reducing of the nonanatomic absorbance by optimizing the drying temperatures, the calcination and atomization temperatures and the removal of the nonanatomic absorbance with D2 lamp. As a result of the use of the method are presented the concentrations of Pt in the blood or urine of a group of patients in Bucharest, a city with heavy traffic of vehicles. GF-AAS method presented is sensitive, reproducible, and relatively easy to apply with an acceptable cost. With this method, the concentration of Pt can be determined from blood and urine, both in order to establish the degree of contamination with Pt and for monitoring cancer therapy with platinum compounds.

Paper Details

Date Published: 14 December 2016
PDF: 6 pages
Proc. SPIE 10010, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII, 100103J (14 December 2016); doi: 10.1117/12.2248335
Show Author Affiliations
Simona Radu, Univ. Politehnica of Bucharest (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)
Ctr. for Military Medical Scientific Research (Romania)
Radu Alexandru Macovei, Clinical Emergency Hospital Bucharest (Romania)
Univ. of Medicine and Pharmacy "Carol Davila" Bucharest (Romania)
Genica Caragea, Ctr. for Military Medical Scientific Research (Romania)
Clinical Emergency Hospital Bucharest (Romania)
Mărgărita Forje, Ctr. for Military Medical Scientific Research (Romania)
Iulia Grecu, Univ. Politehnica of Bucharest (Romania)
Marian Vlădescu, Univ. Politehnica of Bucharest (Romania)
Oana Viscol, Clinical Emergency Hospital Bucharest (Romania)


Published in SPIE Proceedings Vol. 10010:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII
Marian Vladescu; Cornel T. Panait; Razvan Tamas; George Caruntu; Ionica Cristea, Editor(s)

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