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Proceedings Paper

Application of LaserBreath-001 for breath acetone measurement in subjects with diabetes mellitus
Author(s): Zhennan Wang; Meixiu Sun; Zhuying Chen; Xiaomeng Zhao; Yingxin Li; Chuji Wang
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Paper Abstract

Breath acetone is a promising biomarker of diabetes mellitus. With an integrated standalone, on-site cavity ringdown breath acetone analyzer, LaserBreath-001, we tested breath samples from 23 type 1 diabetic (T1D) patients, 312 type 2 diabetic (T2D) patients, 52 healthy subjects. In the cross-sectional studies, the obtained breath acetone concentrations were higher in the diabetic subjects compared with those in the control group. No correlation between breath acetone and simultaneous BG was observed in the T1D, T2D, and healthy subjects. A moderate positive correlation between the mean individual breath acetone concentrations and the mean individual BG levels was observed in the 20 T1D patients without ketoacidosis. In a longitudinal study, the breath acetone concentrations in a T1D patient with ketoacidosis decreased significantly and remained stable during the 5-day hospitalization. The results from a relatively large number of subjects tested indicate that an elevated mean breath acetone concentration exists in diabetic patients in general. Although many physiological parameters affect breath acetone concentrations, fast (<1 min) and on site breath acetone measurement can be used for diabetic screening and management under a specifically controlled condition.

Paper Details

Date Published: 14 November 2016
PDF: 6 pages
Proc. SPIE 10025, Advanced Sensor Systems and Applications VII, 100250S (14 November 2016); doi: 10.1117/12.2246152
Show Author Affiliations
Zhennan Wang, Chinese Academy of Medical Sciences (China)
Peking Union Medical College (China)
Meixiu Sun, Chinese Academy of Medical Sciences (China)
Peking Union Medical College (China)
Zhuying Chen, Chinese Academy of Medical Sciences (China)
Peking Union Medical College (China)
Xiaomeng Zhao, Chinese Academy of Medical Sciences (China)
Peking Union Medical College (China)
Yingxin Li, Chinese Academy of Medical Sciences (China)
Peking Union Medical College (China)
Chuji Wang, Mississippi State Univ. (United States)


Published in SPIE Proceedings Vol. 10025:
Advanced Sensor Systems and Applications VII
Tiegen Liu; Shibin Jiang; Rene Landgraf, Editor(s)

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