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Proceedings Paper

Childhood lymphoblastic leukemia adverse drug reactions: study of risk factors and therapy prognosis by optical methods
Author(s): A. Zyubin; A. Lavrova; S. Babak; V. Malashchenko; A. Borisova; N. Opryshko
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Paper Abstract

The treatment of acute lymphoblastic leukemia (ALL) can result in the side-effects such as kidney affection, hepatic failure and tissue hypoxia. We study dynamics of special biochemical marker of these pathologies - adenosine triphosphate, that is well-known substance of energy metabolism. We use methods of confocal microscopy for determining the cellular and mitochondrial concentration of adenosine triphosphate (ATP). Quantitative values of adenosine triphosphate were calculated for each patient and correlation with degree of side-effects had been done. The application of confocal microscopy for studying of side-effects and therapy of lymphoblastic leukemia is discussed.

Paper Details

Date Published: 31 October 2016
PDF: 6 pages
Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 1002432 (31 October 2016); doi: 10.1117/12.2246024
Show Author Affiliations
A. Zyubin, Immanuel Kant Baltic Federal Univ. (Russian Federation)
A. Lavrova, Immanuel Kant Baltic Federal Univ. (Russian Federation)
S. Babak, Immanuel Kant Baltic Federal Univ. (Russian Federation)
V. Malashchenko, Immanuel Kant Baltic Federal Univ. (Russian Federation)
A. Borisova, Immanuel Kant Baltic Federal Univ. (Russian Federation)
N. Opryshko, Immanuel Kant Baltic Federal Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10024:
Optics in Health Care and Biomedical Optics VII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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