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Proceedings Paper

Differentiation of highly metastatic nasopharyngeal carcinoma cells using multiphoton microscopy
Author(s): Zhenlin Zhan; Zhenzhen Sun; Jingwen Li; Qing Ye; Shuangmu Zhuo; Shusen Xie
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Paper Abstract

The primary hypothesis tested in the study was that nasopharyngeal carcinoma (NPC) cells at different stage of invasion and metastasis can be differentiated using multiphoton microscopy (MPM). CNE1 and CNE2Z cells were cultured and used in this study. The activity of cell migration and invasion was measured using Transwell assays. At the same time, the morphologic features were quantified from the multiphoton images. The measurements of Transwell migration and invasion showed that the invasion and migration of CNE2Z cells were significantly enhanced when compared with that of CNE1 cells. Also, statistically significant differences in the morphologic features were found between two kinds of cancer cells. In conclusion, it is feasible to use MPM to differentiate cancer cells with different stage of invasion and metastasis.

Paper Details

Date Published: 31 October 2016
PDF: 7 pages
Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 1002430 (31 October 2016); doi: 10.1117/12.2245983
Show Author Affiliations
Zhenlin Zhan, Fujian Normal Univ. (China)
Zhenzhen Sun, Fujian Medical Univ. (China)
Fujian Provincial Hospital (China)
Jingwen Li, Fujian Normal Univ. (China)
Qing Ye, Fujian Medical Univ. (China)
Fujian Provincial Hospital (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 10024:
Optics in Health Care and Biomedical Optics VII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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