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Proceedings Paper

Measuring blood oxygenation of pulsatile arteries using photoacoustic microscopy
Author(s): Qian Li; Tianhao Yu; Lin Li; Xinyu Chai; Chuanqing Zhou
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Paper Abstract

Heart pumps blood through the blood vessels to provide body with oxygen and nutrients. As the result, the blood flow, volume and oxygenation in arteries has a pulsatile nature. Measuring these pulsatile parameters enables more precise monitoring of oxygen metabolic rate and is thus valuable for researches and clinical applications. Photoacoustic microscopy (PAM) is a proven label-free method for in vivo measuring blood oxygenation at single blood vessel level. However, studies using PAM to observe the pulsatile nature of blood oxygenation in arteries were not reported. In this paper, we use optical-resolution PAM (OR-PAM) technology to study the blood oxygenation dynamics of pulsatile arteries. First, the ability of our OR-PAM system to accurately reflect the change of optical absorption in imaged objects is demonstrated in a phantom study. Then the system is used to image exposed cortical blood vessels of cat. The pulsatile nature of blood volume and oxygenation in arteries is clearly reflected in photoacoustic (PA) signals, whereas it’s not observable in veins. By using a multi-wavelength laser, the dynamics of the blood oxygenation of pulsatile arteries in cardiac cycles can be measured, based on the spectroscopic method.

Paper Details

Date Published: 31 October 2016
PDF: 7 pages
Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242E (31 October 2016); doi: 10.1117/12.2245686
Show Author Affiliations
Qian Li, Shanghai Jiao Tong Univ. (China)
Tianhao Yu, Shanghai Jiao Tong Univ. (China)
Lin Li, Shanghai Jiao Tong Univ. (China)
Xinyu Chai, Shanghai Jiao Tong Univ. (China)
Chuanqing Zhou, Shanghai Jiao Tong Univ. (China)


Published in SPIE Proceedings Vol. 10024:
Optics in Health Care and Biomedical Optics VII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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