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Proceedings Paper

Numerical simulation and analysis of accurate blood oxygenation measurement by using optical resolution photoacoustic microscopy
Author(s): Tianhao Yu; Qian Li; Lin Li; Chuanqing Zhou
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Paper Abstract

Accuracy of photoacoustic signal is the crux on measurement of oxygen saturation in functional photoacoustic imaging, which is influenced by factors such as defocus of laser beam, curve shape of large vessels and nonlinear saturation effect of optical absorption in biological tissues. We apply Monte Carlo model to simulate energy deposition in tissues and obtain photoacoustic signals reaching a simulated focused surface detector to investigate corresponding influence of these factors. We also apply compensation on photoacoustic imaging of in vivo cat cerebral cortex blood vessels, in which signals from different lateral positions of vessels are corrected based on simulation results. And this process on photoacoustic images can improve the smoothness and accuracy of oxygen saturation results.

Paper Details

Date Published: 31 October 2016
PDF: 10 pages
Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242C (31 October 2016); doi: 10.1117/12.2245681
Show Author Affiliations
Tianhao Yu, Shanghai Jiao Tong Univ. (China)
Qian Li, Shanghai Jiao Tong Univ. (China)
Lin Li, Shanghai Jiao Tong Univ. (China)
Chuanqing Zhou, Shanghai Jiao Tong Univ. (China)

Published in SPIE Proceedings Vol. 10024:
Optics in Health Care and Biomedical Optics VII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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