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Proceedings Paper

Identification of tumor cells infiltrating into connective tissue in esophageal cancer by multiphoton microscopy
Author(s): Jian Xu; Liwei Jiang; Deyong Kang; Xuejing Wu; Meifang Xu; Shuangmu Zhuo; Xiaoqin Zhu; Jiangbo Lin; Jianxin Chen
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Paper Abstract

Esophageal cancer is one of the most common malignancies of the gastrointestinal cancers and carries poorer prognosis than other gastrointestinal cancers. In general practice, the depth of tumor infiltration in esophageal wall is crucial to establishing appropriate treatment plan which is established by detecting the tumor infiltration depth. Connective tissue is one of the main structures that form the esophageal wall. So, identification of tumor cells infiltrating into connective tissue is helping for detecting the tumor infiltration depth. Our aim is to evaluate whether multiphoton microscopy (MPM) can be used to detect tumor cells infiltrating into connective tissue in the esophageal cancer. MPM is well-suited for real-time detecting morphologic and cellular changes in fresh tissues since many endogenous fluorophores of fresh tissues are excited through two-photon excited fluorescence (TPEF) and second harmonic generation (SHG). In this work, microstructure of tumor cells and connective tissue are first studied. Then, morphological changes of collagen fibers after the infiltration of tumor cells are shown. These results show that MPM has the ability to detect tumor cells infiltrating into connective tissue in the esophageal cancer. In the future, MPM may be a promising imaging technique for detecting tumor cells in esophageal cancer.

Paper Details

Date Published: 31 October 2016
PDF: 6 pages
Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100241Z (31 October 2016); doi: 10.1117/12.2245379
Show Author Affiliations
Jian Xu, Fujian Normal Univ. (China)
Liwei Jiang, Fujian Normal Univ. (China)
Chung Yuan Christian Univ. (China)
Deyong Kang, Fujian Medical Univ. (China)
Xuejing Wu, Fujian Medical Univ. (China)
Meifang Xu, Fujian Medical Univ. (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)
Xiaoqin Zhu, Fujian Normal Univ. (China)
Jiangbo Lin, Fujian Medical Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 10024:
Optics in Health Care and Biomedical Optics VII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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