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Proceedings Paper

Seed mediated one-pot growth of versatile heterogeneous upconversion nanocrystals for multimodal bioimaging
Author(s): Shihui Wen; Du Li; Deming Liu; Xiaoxue Xu; Yi Du; David R. G. Mitchell; Bingyang Shi; Xiangyang Shi; Dayong Jin
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Paper Abstract

The rapid development of a variety of molecular contrast agents makes the multimodality bioimaging highly attractive towards higher resolution, more sensitive, informative diagnosis. The key lies in the development of facile material synthesis that allows the integration of multiple contrast agents, ideally in a way that each of the components should be logically assembled to maximize their performances. Here, we report the one-pot programmable growth of multifunctional heterogeneous nanocrystal with tunable size, shape, composition, and properties. We demonstrated a facile one-pot hot-injection method to enable the highly selectively controlled growth of different sodium lanthanide fluoride nanomaterials in either longitudinal or transversal directions with atomic scale precision. This technique allows the upconversion luminescence signal, MRI signal and x-ray signal logically integrated and optimized within one single versatile nanoplatform for multimode bioimaging. These findings suggest that the facile strategy developed here have the promising to get the desired heterogeneous nanocrystals as an all-in-one contrast agent for integrated and self-correlative multimodal bioimaging.

Paper Details

Date Published: 9 December 2016
PDF: 7 pages
Proc. SPIE 10013, SPIE BioPhotonics Australasia, 1001315 (9 December 2016); doi: 10.1117/12.2245172
Show Author Affiliations
Shihui Wen, Univ. of Technology, Sydney (Australia)
ARC Ctr. of Excellence for Nanoscale BioPhotonics, Macquarie Univ. (Australia)
Du Li, Univ. of Technology, Sydney (Australia)
ARC Ctr. of Excellence for Nanoscale BioPhotonics, Macquarie Univ. (Australia)
Donghua Univ. (China)
Deming Liu, Univ. of Technology, Sydney (Australia)
ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
Macquarie Univ. (Australia)
Xiaoxue Xu, Univ. of Technology, Sydney (Australia)
ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
Macquarie Univ. (Australia)
Yi Du, Univ. of Wollongong (Australia)
David R. G. Mitchell, Univ. of Wollongong (Australia)
Bingyang Shi, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
Macquarie Univ. (Australia)
Xiangyang Shi, Donghua Univ. (China)
Dayong Jin, Univ. of Technology, Sydney (Australia)
ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
Macquarie Univ. (Australia)


Published in SPIE Proceedings Vol. 10013:
SPIE BioPhotonics Australasia
Mark R. Hutchinson; Ewa M. Goldys, Editor(s)

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