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Proceedings Paper

Ionization pattern obtained in electrospray ionization or atmospheric pressure chemical ionization interfaces for authorized antidepressants in Romania
Author(s): Iulia Grecu; Mihai Ionică; Marian Vlădescu; Elena Truţă; Carmen Sultan; Oana Viscol; Luminiţa Horhotă; Simona Radu
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Paper Abstract

Antidepressants were found in 1950. In the 1990s there was a new generation of antidepressants. They act on the level of certain neurotransmitters extrasinpatic by its growth. After their mode of action antidepressants may be: SSRIs (Selective Serotonin Reuptake Inhibitors); (Serotonin-Norepinephrine Reuptake Inhibitors); SARIs (Serotonin Antagonist Reuptake Inhibitors); NRIs (Norepinephrine Reuptake Inhibitors); NDRIs (Norepinephrine-Dopamine Reuptake Inhibitors) NDRAs (Norepinephrine-Dopamine Releasing Agents); TCAs (Tricyclic Antidepressants); TeCAs (Tetracyclic Antidepressants); MAOIs (Monoamine Oxidase Inhibitors); agonist receptor 5-HT1A (5- hydroxytryptamine); antagonist receptor 5-HT2; SSREs (Selective Serotonin Reuptake Enhancers) and Sigma agonist receptor.

To determine the presence of antidepressants in biological products, it has been used a system HPLC-MS (High Performance Liquid Chromatography – Mass Spectrometry) Varian 12001. The system is equipped with APCI (Atmospheric Pressure Chemical Ionization) or ESI (ElectroSpray Ionization) interface. To find antidepressants in unknown samples is necessary to recognize them after mass spectrum. Because the mass spectrum it is dependent on obtaining private parameters work of HPLC-MS system, and control interfaces, the mass spectra library was filled with the mass spectra of all approved antidepressants in Romania. The paper shows the mass spectra obtained in the HPLCMS system.

Paper Details

Date Published: 14 December 2016
PDF: 4 pages
Proc. SPIE 10010, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII, 100103H (14 December 2016); doi: 10.1117/12.2243420
Show Author Affiliations
Iulia Grecu, Univ. Politehnica of Bucharest (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)
Ctr. for Military Medical Scientific Research (Romania)
Marian Vlădescu, Univ. Politehnica of Bucharest (Romania)
Elena Truţă, Clinical Emergency Hospital Bucharest (Romania)
Carmen Sultan, Clinical Emergency Hospital Bucharest (Romania)
Oana Viscol, Clinical Emergency Hospital Bucharest (Romania)
Luminiţa Horhotă, Ctr. for Military Medical Scientific Research (Romania)
Simona Radu, Univ. Politehnica of Bucharest (Romania)


Published in SPIE Proceedings Vol. 10010:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VIII
Marian Vladescu; Cornel T. Panait; Razvan Tamas; George Caruntu; Ionica Cristea, Editor(s)

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