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Proceedings Paper

Non-invasive assessment of the liver using imaging
Author(s): Camilla Thorling Thompson; Haolu Wang; Xin Liu; Xiaowen Liang; Darrell HG Crawford; Michael S. Roberts
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Paper Abstract

Chronic liver disease causes 2,000 deaths in Australia per year and early diagnosis is crucial to avoid progression to cirrhosis and end stage liver disease. There is no ideal method to evaluate liver function. Blood tests and liver biopsies provide spot examinations and are unable to track changes in function quickly. Therefore better techniques are needed. Non-invasive imaging has the potential to extract increased information over a large sampling area, continuously tracking dynamic changes in liver function. This project aimed to study the ability of three imaging techniques, multiphoton and fluorescence lifetime imaging microscopy, infrared thermography and photoacoustic imaging, in measuring liver function. Collagen deposition was obvious in multiphoton and fluorescence lifetime imaging in fibrosis and cirrhosis and comparable to conventional histology. Infrared thermography revealed a significantly increased liver temperature in hepatocellular carcinoma. In addition, multiphoton and fluorescence lifetime imaging and photoacoustic imaging could both track uptake and excretion of indocyanine green in rat liver. These results prove that non-invasive imaging can extract crucial information about the liver continuously over time and has the potential to be translated into clinic in the assessment of liver disease.

Paper Details

Date Published: 9 December 2016
PDF: 5 pages
Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100131J (9 December 2016); doi: 10.1117/12.2242883
Show Author Affiliations
Camilla Thorling Thompson, The Univ. of Queensland (Australia)
Haolu Wang, The Univ. of Queensland (Australia)
Xin Liu, The Univ. of Queensland (Australia)
Xiaowen Liang, The Univ. of Queensland (Australia)
Darrell HG Crawford, The Univ. of Queensland (Australia)
Michael S. Roberts, The Univ. of Queensland (Australia)
The Univ. of South Australia (Australia)


Published in SPIE Proceedings Vol. 10013:
SPIE BioPhotonics Australasia
Mark R. Hutchinson; Ewa M. Goldys, Editor(s)

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