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Proceedings Paper

Shapeshifting photoswitchable azobenzene compounds and their biological applications
Author(s): Victoria Peddie; Sabrina Heng; Sanam Mustafa; Jacob Thomas; Mark R. Hutchinson; Andrew D. Abell
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Paper Abstract

The photoisomerisation of azobenzenes between trans and cis results in well-defined changes in geometry and a considerable change of polarity. Thus, incorporating an azobenezene into a bioactive compound provides an opportunity to control biological activity, with ideally one configuration being active and the other inactive. This can allow the role of a specific biomolecule to be probed in its native environment by controlling activity both spatially and temporally using light. Incorporating such a photoswitchable moiety into the structure of a known GRK2 inhibitor can generate photoswitchable inhibitors, which can be used to reversibly regulate the activity of GRK2, and hence GPRCs.

Paper Details

Date Published: 24 November 2016
PDF: 4 pages
Proc. SPIE 10013, SPIE BioPhotonics Australasia, 100132W (24 November 2016); doi: 10.1117/12.2242356
Show Author Affiliations
Victoria Peddie, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
The Univ. of Adelaide (Australia)
Sabrina Heng, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
The Univ. of Adelaide (Australia)
Sanam Mustafa, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
The Univ. of Adelaide (Australia)
Jacob Thomas, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
The Univ. of Adelaide (Australia)
Mark R. Hutchinson, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
The Univ. of Adelaide (Australia)
Andrew D. Abell, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
The Univ. of Adelaide (Australia)


Published in SPIE Proceedings Vol. 10013:
SPIE BioPhotonics Australasia
Mark R. Hutchinson; Ewa M. Goldys, Editor(s)

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