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Proceedings Paper

Light-based theranostics using hybrid structures derived from biological and organic materials
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Paper Abstract

We have engineered hybrid nanostructures derived from erythrocytes, which can be doped with various near infrared (NIR) organic chromophores, including the FDA-approved indocyanine green (ICG). We refer to these vesicles as NIR erythrocyte-mimicking transducers (NETs), as they are capable of generating heat, reactive oxygen species (ROS) or emit fluorescence light. We present preliminary results that demonstrate the effectiveness of NETs for fluorescence imaging and photodynamic therapeutic destruction of breast cancer cells, upon photo-excitation using NIR light. These hybrid nanostructures present a promising platform with theranostic capability for future biomedical clinical applications.

Paper Details

Date Published: 27 September 2016
PDF: 5 pages
Proc. SPIE 9930, Biosensing and Nanomedicine IX, 993008 (27 September 2016); doi: 10.1117/12.2238406
Show Author Affiliations
Raviraj Vankayala, Univ. of California, Riverside (United States)
Joshua M. Burns, Univ. of California, Riverside (United States)
Jenny T. Mac, Univ. of California, Riverside (United States)
Bahman Anvari, Univ. of California, Riverside (United States)

Published in SPIE Proceedings Vol. 9930:
Biosensing and Nanomedicine IX
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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