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Performance assessment of polymer based electrodes for in vitro electrophysiological sensing: the role of the electrode impedance
Author(s): Maria C. R. Medeiros; Ana L. G. Mestre; Pedro M. C. Inácio; João M. L. Santos; Inês M. Araujo; José Bragança; Fabio Biscarini; Henrique L. Gomes
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Paper Abstract

Conducting polymer electrodes based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) are used to record extracellular signals from autonomous cardiac contractile cells and glioma cell cultures. The performance of these conducting polymer electrodes is compared with Au electrodes. A small-signal impedance analysis shows that in the presence of an electrolyte, both Au and polymer electrodes establish high capacitive double-layers. However, the polymer/electrolyte interfacial resistance is 3 orders of magnitude lower than the resistance of the metal/electrolyte interface. The polymer low interfacial resistance minimizes the intrinsic thermal noise and increases the system sensitivity. However, when measurements are carried out in current mode a low interfacial resistance partially acts as a short circuit of the interfacial capacitance, this affects the signal shape.

Paper Details

Date Published: 27 September 2016
PDF: 8 pages
Proc. SPIE 9944, Organic Sensors and Bioelectronics IX, 994404 (27 September 2016); doi: 10.1117/12.2237659
Show Author Affiliations
Maria C. R. Medeiros, Univ. de Coimbra (Portugal)
Ana L. G. Mestre, Univ. do Algarve (Portugal)
Instituto de Telecomunicações (Portugal)
Pedro M. C. Inácio, Univ. do Algarve (Portugal)
Instituto de Telecomunicações (Portugal)
João M. L. Santos, Univ. do Algarve (Portugal)
Inês M. Araujo, Univ. do Algarve (Portugal)
José Bragança, Univ. do Algarve (Portugal)
Fabio Biscarini, Univ. degli Studi di Modena e Reggio Emilia (Italy)
Henrique L. Gomes, Univ. do Algarve (Portugal)
Instituto de Telecomunicações (Portugal)

Published in SPIE Proceedings Vol. 9944:
Organic Sensors and Bioelectronics IX
Ioannis Kymissis; Ruth Shinar; Luisa Torsi, Editor(s)

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