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Evaluation of the degradation behavior of resorbable metal implants for in vivo osteosynthesis by synchrotron radiation based x-ray tomography and histology
Author(s): Silvia Galli; Jörg U. Hammel; Julia Herzen; Timo Damm; Ryo Jimbo; Felix Beckmann; Ann Wennerberg; Regine Willumeit-Römer
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Paper Abstract

Magnesium(Mg)-alloys are promising candidates as temporary implants for orthopedic and cranio-facial applications. They can sustain tissues during healing, thanks to favorable mechanical properties, and then they slowly degrade into biocompatible products, avoiding the need of a second surgery for implant removal. They have the potential to benefit a vast number of patients, especially children and elderly patients. However, to be able to tailor their degradation to match the speed of tissue regeneration it is crucial to understand how they actually degrade in the living organism. We utilized high-resolution synchrotron-based tomography at the beamline P05 operated by HZG at the storage ring PETRA III at DESY to study the degradation of 3 novel Mg-alloys in rat bone and the consequent bone response. On threedimensional reconstructions of the bone-implant explants we were able to follow the dynamic transformation that the materials underwent at different healing times and on the basis of absorption coefficients we could distinguish and quantify the amount of remaining implants, the corrosion layers and the new bone. This was a great advantage compared to laboratory CT, for which the limitation in contrast and in resolution made impossible to discriminate between original alloy, degradation products and bone, leading to inaccurate determination of the materials degradation rates. The same samples imaged by tomography were used for non-decalcified histology. The combination of histological and tomographical images provided new insight on the nature of the bone-to-implant interface and of the degradation products, which appeared to have great similarities to the host bone.

Paper Details

Date Published: 4 October 2016
PDF: 13 pages
Proc. SPIE 9967, Developments in X-Ray Tomography X, 996704 (4 October 2016); doi: 10.1117/12.2237563
Show Author Affiliations
Silvia Galli, Malmö Univ. (Sweden)
Jörg U. Hammel, Helmholtz-Zentrum Geesthacht (Germany)
Julia Herzen, Technische Univ. München (Germany)
Timo Damm, Univ. Hospital Schleswig-Holstein (Germany)
Ryo Jimbo, Malmö Univ. (Sweden)
Felix Beckmann, Helmholtz-Zentrum Geesthacht (Germany)
Ann Wennerberg, Malmö Univ. (Sweden)
Regine Willumeit-Römer, Helmholtz-Zentrum Geesthacht (Germany)

Published in SPIE Proceedings Vol. 9967:
Developments in X-Ray Tomography X
Stuart R. Stock; Bert Müller; Ge Wang, Editor(s)

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