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Biocompatibility of modified ultra-high-molecular-weight polyethylene
Author(s): Z. Novotná; V. Lacmanová; S. Rimpelová; P. Juřik; M. Polívková; V. Švorčik
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Paper Abstract

Ultra-high-molecular-weight polyethylene (UHMWPE, PE) is a synthetic polymer used for biomedical applications because of its high impact resistance, ductility and stability in contact with physiological fluids. Therefore this material is being used in human orthopedic implants such as total joint replacements. Surface modification of this material relates to changes of its surface hydrophilicity, energy, microstructure, roughness, and morphology, all influencing its biological response.

In our recent work, PE was treated by an Ar+ plasma discharge and then grafted with biologically active polyethylene glycol in order to enhance adhesion and proliferation of mouse fibroblast (L929). The surface properties of pristine PE and its grafted counterparts were studied by goniometry (surface wettability). Furthermore, Atomic Force Microscopy was used to determine the surface morphology and roughness. The biological response of the L929 cell lines seeded on untreated and plasma treated PE matrices was quantified in terms of the cell adhesion, density, and metabolic activity.

Plasma treatment leads to the ablation of the polymer surface layers. Plasma treatment and subsequent poly(ethylene glycol) grafting lead to dramatic changes in the polymer surface morphology and roughness. Biological tests, performed in vitro, show increased adhesion and proliferation of cells on modified polymers. Grafting with poly(ethylene glycol) increases cell proliferation compared to plasma treatment.

Paper Details

Date Published: 27 September 2016
PDF: 7 pages
Proc. SPIE 9930, Biosensing and Nanomedicine IX, 99300Y (27 September 2016); doi: 10.1117/12.2237379
Show Author Affiliations
Z. Novotná, Univ. of Chemistry and Technology (Czech Republic)
V. Lacmanová, Univ. of Chemistry and Technology (Czech Republic)
S. Rimpelová, Univ. of Chemistry and Technology (Czech Republic)
P. Juřik, Univ. of Chemistry and Technology (Czech Republic)
M. Polívková, Univ. of Chemistry and Technology (Czech Republic)
V. Švorčik, Univ. of Chemistry and Technology (Czech Republic)


Published in SPIE Proceedings Vol. 9930:
Biosensing and Nanomedicine IX
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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