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Proceedings Paper

Chiral liquid crystals as biosensing platforms
Author(s): Mon-Juan Lee; Yu-Chien Sung; Yu-Cheng Hsiao; Wei Lee
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Paper Abstract

The texture observation has long been the core technique in liquid crystal (LC)-based bioassays. Its working principle stems from the dark-to-bright texture change induced by the interruption of the initially homeotropic alignment in nematic bulks or from the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. One of the drawbacks of this observational scheme, which requires a polarizing optical microscope, is the difficulty in quantitative analysis. In this invited paper, we report on our recent development of alternative optical biosensing techniques based on cholesteric LCs (CLCs) without the use of a polarizer. The increase in structural order in a vertically anchored CLC cell in the quasi-planar state provides a means to allow detection and quantification of the concentration of biomolecules immobilized on the interface between the mesophase and the surfactant DMOAP for LC vertical alignment.

Paper Details

Date Published: 23 September 2016
PDF: 6 pages
Proc. SPIE 9940, Liquid Crystals XX, 99400K (23 September 2016); doi: 10.1117/12.2236774
Show Author Affiliations
Mon-Juan Lee, Chang Jung Christian Univ. (Taiwan)
Yu-Chien Sung, National Chiao Tung Univ. (Taiwan)
Yu-Cheng Hsiao, National Chiao Tung Univ. (Taiwan)
Wei Lee, National Chiao Tung Univ. (Taiwan)

Published in SPIE Proceedings Vol. 9940:
Liquid Crystals XX
Iam Choon Khoo, Editor(s)

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