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Proceedings Paper

High resolution microendoscopy for early detection of esophageal cancer in low-resource settings (Conference Presentation)
Author(s): Rebecca Richards-Kortum
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Paper Abstract

Esophageal squamous cell neoplasia (ESCN) is the sixth leading cause of cancer death worldwide. Most deaths due to ESCN occur in developing countries, with highest risk areas in northern China. Lugol’s chromoendoscopy (LCE) is the gold-standard for ESCN screening; while the sensitivity of LCE for ESCN is >95%, LCE suffers poor specificity (< 65%) due to false positive findings from inflammatory lesions. High resolution microendoscopy (HRME) uses a low-cost, fiber-optic fluorescence microscope to image morphology of the surface epithelium without need for biopsy. We developed a tablet-interfaced HRME with automated, real-time image analysis. In an in vivo study of 177 patients referred for endoscopy in China, use of the algorithm identified neoplasia with a sensitivity and specificity of 95% and 91% compared to the gold standard of histology.

Paper Details

Date Published: 27 April 2016
PDF: 1 pages
Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 969104 (27 April 2016); doi: 10.1117/12.2229789
Show Author Affiliations
Rebecca Richards-Kortum, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 9691:
Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III
Melissa J. Suter; Stephen Lam; Matthew Brenner; Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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