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Proceedings Paper

Gold nanocages for imaging and therapy of prostate cancer cells
Author(s): Laura Sironi; Svetlana Avvakumova; Elisabetta Galbiati; Silvia A. Locarno; Chiara Macchi; Laura D'Alfonso; Massimiliano Ruscica; Paolo Magni; Maddalena Collini; Sergio Romeo; Giuseppe Chirico; Davide Prosperi
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Paper Abstract

Gold nanocages (AuNCs) have been shown to be a useful tool both for imaging and hyperthermia therapy of cancer, thanks to their outstanding optical properties, low toxicity and facile functionalization with targeting molecules, including peptides and antibodies. In particular, hyperthermia is a minimally invasive therapy which takes advantage of the peculiar properties of gold nanoparticles to efficiently convert the absorbed light into heat. Here, we use AuNCs for the selective targeting and imaging of prostate cancer cells. Moreover, we report the hyperthermic effect characterization of the AuNCs both in solution and internalized in cells. Prostate cancer cells were irradiated at different exposure times, with a pulsed near infrared laser, and the cellular viability was evaluated by confocal microscopy.

Paper Details

Date Published: 27 April 2016
PDF: 10 pages
Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 988721 (27 April 2016); doi: 10.1117/12.2229715
Show Author Affiliations
Laura Sironi, Univ. degli Studi di Milano-Bicocca (Italy)
Svetlana Avvakumova, Univ. degli Studi di Milano-Bicocca (Italy)
Elisabetta Galbiati, Univ. degli Studi di Milano-Bicocca (Italy)
Silvia A. Locarno, Univ. degli Studi di Milano (Italy)
Chiara Macchi, Univ. degli Studi di Milano (Italy)
Laura D'Alfonso, Univ. degli Studi di Milano-Bicocca (Italy)
Massimiliano Ruscica, Univ. degli Studi di Milano (Italy)
Paolo Magni, Univ. degli Studi di Milano (Italy)
Maddalena Collini, Univ. degli Studi di Milano-Bicocca (Italy)
Sergio Romeo, Univ. degli Studi di Milano (Italy)
Giuseppe Chirico, Univ. degli Studi di Milano-Bicocca (Italy)
Davide Prosperi, Univ. degli Studi di Milano-Bicocca (Italy)


Published in SPIE Proceedings Vol. 9887:
Biophotonics: Photonic Solutions for Better Health Care V
Jürgen Popp; Valery V. Tuchin; Dennis L. Matthews; Francesco Saverio Pavone, Editor(s)

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