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Proceedings Paper

In vitro metabolism study of normal and tumor cells when exposed to red LED light
Author(s): Olga V. Stolbovskaya; Radik M. Khairullin; Yuri V. Saenko; Ekaterina S. Krasnikova; Aleksandr V. Krasnikov; Aleksandr A. Fomin; Aleksandr A. Skaptsov
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Paper Abstract

This work presents the results of studying the mitochondrial membrane potential, intracellular ROS, peculiarities of the cell cycle of cancer cells HCT-116 and the normal line of CHO cells when exposed to the red LED light with a wavelength range of 0.620-0.680 μm. A dose-dependent increase in mitochondrial membrane potential and intracellular ROS concentration in cancer cells HCT-116 was established. In normal CHO cell line a dose-dependent reduction of mitochondrial membrane potential and dose-dependent increase in intracellular ROS occur. It has been shown that the sensitivity of the studied cell lines to the red light depends on the stage of the cell cycle.

Paper Details

Date Published: 21 April 2016
PDF: 6 pages
Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171Q (21 April 2016); doi: 10.1117/12.2229614
Show Author Affiliations
Olga V. Stolbovskaya, Ulyanovsk State Univ. (Russian Federation)
Radik M. Khairullin, Ulyanovsk State Univ. (Russian Federation)
Yuri V. Saenko, Ulyanovsk State Univ. (Russian Federation)
Ekaterina S. Krasnikova, Saratov State Agrarian Univ. (Russian Federation)
Aleksandr V. Krasnikov, Saratov State Agrarian Univ. (Russian Federation)
Aleksandr A. Fomin, Yuri Gagarin State Technical Univ. of Saratov (Russian Federation)
Aleksandr A. Skaptsov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 9917:
Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS)
Elina A. Genina; Valery V. Tuchin; Vladimir L. Derbov; Dmitry E. Postnov; Igor V. Meglinski; Kirill V. Larin; Alexander Borisovich Pravdin, Editor(s)

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