Share Email Print
cover

Proceedings Paper

The study of the structural features of the lymphocytes in patients with diabetes using atomic force microscopy
Author(s): Olga V. Stolbovskaya; Radik M. Khairullin; Boris B. Kostishko; Ekaterina S. Pchelintseva; Ekaterina S. Krasnikova; Aleksandr A. Fomin; Aleksandr A. Skaptsov
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The results of the study of morphological and biophysical parameters of the cell membrane of live lymphocytes in patients with insulin-dependent and non-insulin dependent diabetes mellitus and healthy donors using atomic force microscopy have been presented. It is found that lymphocytes from patients with diabetes are characterized by a decrease in volume and cell surface roughness compared to normal lymphocytes. An increase in the Young's modulus of lymphocytes in patients with diabetes more than 3 times compared to normal rates has been shown. Increased stiffening of lymphocyte cytolemma in patients with non-insulin dependent diabetes mellitus leads to a decrease in its adhesive properties, unlike lymphocytes in patients with insulin-dependent diabetes mellitus.

Paper Details

Date Published: 21 April 2016
PDF: 6 pages
Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171P (21 April 2016); doi: 10.1117/12.2229609
Show Author Affiliations
Olga V. Stolbovskaya, Ulyanovsk State Univ. (Russian Federation)
Radik M. Khairullin, Ulyanovsk State Univ. (Russian Federation)
Boris B. Kostishko, Ulyanovsk State Univ. (Russian Federation)
Ekaterina S. Pchelintseva, Ulyanovsk State Univ. (Russian Federation)
Ekaterina S. Krasnikova, Saratov State Agrarian Univ. (Russian Federation)
Aleksandr A. Fomin, Yuri Gagarin State Technical Univ. of Saratov (Russian Federation)
Aleksandr A. Skaptsov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 9917:
Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS)
Elina A. Genina; Valery V. Tuchin; Vladimir L. Derbov; Dmitry E. Postnov; Igor V. Meglinski; Kirill V. Larin; Alexander Borisovich Pravdin, Editor(s)

© SPIE. Terms of Use
Back to Top