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Proceedings Paper

Determination of type and concentration of DNA nitrogenous bases by Raman spectroscopy using artificial neural networks
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Paper Abstract

In this article the results of solution of two-parametrical inverse problems of laser Raman spectroscopy of identification and determination of concentration of DNA nitrogenous bases in two-component solutions are presented. Elaboration of methods of control of reactions with DNA strands in remote real-time mode is necessary for solution of one of the basic problems of creation of biocomputers – increase of reliability of molecular DNA-computations. The comparative analysis of two used methods of solution of stated problems has demonstrated convincing advantages of technique of artificial neural networks. Use of artificial neural networks allowed to reach the accuracy of determination of concentration of each base in two-component solutions 0.2-0.3 g/l.

Paper Details

Date Published: 21 April 2016
PDF: 11 pages
Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 991717 (21 April 2016); doi: 10.1117/12.2228470
Show Author Affiliations
Kirill A. Laptinskiy, Moscow State Univ. (Russian Federation)
Sergey A. Burikov, Moscow State Univ. (Russian Federation)
Olga E. Sarmanova, Moscow State Univ. (Russian Federation)
Sergey A. Dolenko, D. V. Skobeltsyn Institute of Nuclear Physics (Russian Federation)
Tatiana A. Dolenko, Moscow State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 9917:
Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS)
Elina A. Genina; Valery V. Tuchin; Vladimir L. Derbov; Dmitry E. Postnov; Igor V. Meglinski; Kirill V. Larin; Alexander Borisovich Pravdin, Editor(s)

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