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Proceedings Paper

Towards field malaria diagnosis using surface enhanced Raman spectroscopy
Author(s): Keren Chen; Aoli Xiong; Clement Yuen; Peter Preiser; Quan Liu
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Paper Abstract

We report three strategies of surface enhanced Raman spectroscopy (SERS) for β-hematin and hemozoin detection in malaria infected human blood, which can be potentially developed for field malaria diagnosis. In the first strategy, we used silver coated magnetic nanoparticles (Fe3O4@Ag) in combination with an external magnetic field to enhance the Raman signal of β-hematin. Then we developed two SERS methods without the requirement of magnetic field for malaria infection diagnosis. In Method 1, silver nanoparticles were synthesized separately and then mixed with lysed blood just like in traditional SERS measurements; while in Method 2, we developed an ultrasensitive SERS method by synthesizing silver nanoparticles directly inside the parasites of Plasmodium falciparum. Method 2 can be also used to detect single parasites in the ring stage.

Paper Details

Date Published: 27 April 2016
PDF: 8 pages
Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 98870M (27 April 2016); doi: 10.1117/12.2227042
Show Author Affiliations
Keren Chen, Nanyang Technological Univ. (Singapore)
Aoli Xiong, Nanyang Technological Univ. (Singapore)
Clement Yuen, Nanyang Technological Univ. (Singapore)
Peter Preiser, Nanyang Technological Univ. (Singapore)
Quan Liu, Nanyang Technological Univ. (Singapore)


Published in SPIE Proceedings Vol. 9887:
Biophotonics: Photonic Solutions for Better Health Care V
Jürgen Popp; Valery V. Tuchin; Dennis L. Matthews; Francesco Saverio Pavone, Editor(s)

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