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Proceedings Paper

Development of cadmium-free quantum dot for intracellular labelling through electroporation or lipid-calcium-phosphate
Author(s): Ying-Feng Liu; Wei-Ling Hung; Tzh-Yin Hou; Hsiu-Ying Huang; Cheng-An J. Lin
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Paper Abstract

Traditional fluorescent labelling techniques has severe photo-bleaching problem such as organic dyes and fluorescent protein. Quantum dots made up of traditional semiconductor (CdSe/ZnS) material has sort of biological toxicity. This research has developed novel Cd-free quantum dots divided into semiconductor (Indium phosphide, InP) and noble metal (Gold). Former has lower toxicity compared to traditional quantum dots. Latter consisting of gold (III) chloride (AuCl3) and toluene utilizes sonochemical preparation and different stimulus to regulate fluorescent wavelength. Amphoteric macromolecule surface technology and ligand Exchange in self-Assembled are involved to develop hydrophilic nanomaterials which can regulate the number of grafts per molecule of surface functional groups. Calcium phosphate (CaP) nanoparticle (NP) with an asymmetric lipid bilayer coating technology developed for intracellular delivery and labelling has synthesized Cd-free quantum dots possessing high brightness and multi-fluorescence successfully. Then, polymer coating and ligand exchange transfer to water-soluble materials to produce liposome nanomaterials as fluorescent probes and enhancing medical applications of nanotechnology.

Paper Details

Date Published: 19 April 2016
PDF: 6 pages
Proc. SPIE 9884, Nanophotonics VI, 988428 (19 April 2016); doi: 10.1117/12.2225864
Show Author Affiliations
Ying-Feng Liu, Chung Yuan Christian Univ. (Taiwan)
Wei-Ling Hung, Chung Yuan Christian Univ. (Taiwan)
Tzh-Yin Hou, Chung Yuan Christian Univ. (Taiwan)
Hsiu-Ying Huang, Chung Yuan Christian Univ. (Taiwan)
Cheng-An J. Lin, Chung Yuan Christian Univ. (Taiwan)


Published in SPIE Proceedings Vol. 9884:
Nanophotonics VI
David L. Andrews; Jean-Michel Nunzi; Andreas Ostendorf, Editor(s)

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