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Proceedings Paper

Discrimination of inflammatory bowel disease using Raman spectroscopy and linear discriminant analysis methods
Author(s): Hao Ding; Ming Cao; Andrew W. DuPont; Larry D. Scott; Sushovan Guha; Shashideep Singhal; Mamoun Younes; Isaac Pence; Alan Herline; David Schwartz; Hua Xu; Anita Mahadevan-Jansen; Xiaohong Bi
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Paper Abstract

Inflammatory bowel disease (IBD) is an idiopathic disease that is typically characterized by chronic inflammation of the gastrointestinal tract. Recently much effort has been devoted to the development of novel diagnostic tools that can assist physicians for fast, accurate, and automated diagnosis of the disease. Previous research based on Raman spectroscopy has shown promising results in differentiating IBD patients from normal screening cases. In the current study, we examined IBD patients in vivo through a colonoscope-coupled Raman system. Optical diagnosis for IBD discrimination was conducted based on full-range spectra using multivariate statistical methods. Further, we incorporated several feature selection methods in machine learning into the classification model. The diagnostic performance for disease differentiation was significantly improved after feature selection. Our results showed that improved IBD diagnosis can be achieved using Raman spectroscopy in combination with multivariate analysis and feature selection.

Paper Details

Date Published: 7 March 2016
PDF: 8 pages
Proc. SPIE 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 97040W (7 March 2016); doi: 10.1117/12.2225299
Show Author Affiliations
Hao Ding, The Univ. of Texas Health Science Ctr. at Houston (United States)
Ming Cao, The Univ. of Texas Health Science Ctr. at Houston (United States)
Andrew W. DuPont, The Univ. of Texas Health Science Ctr. at Houston (United States)
Larry D. Scott, The Univ. of Texas Health Science Ctr. at Houston (United States)
Sushovan Guha, The Univ. of Texas Health Science Ctr. at Houston (United States)
Shashideep Singhal, The Univ. of Texas Health Science Ctr. at Houston (United States)
Mamoun Younes, The Univ. of Texas Health Science Ctr. at Houston (United States)
Isaac Pence, Vanderbilt Univ. (United States)
Alan Herline, Vanderbilt Univ. (United States)
David Schwartz, Vanderbilt Univ. Medical Ctr. (United States)
Hua Xu, The Univ. of Texas Health Science Ctr. at Houston (United States)
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)
Xiaohong Bi, The Univ. of Texas Health Science Ctr. at Houston (United States)


Published in SPIE Proceedings Vol. 9704:
Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

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