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Proceedings Paper

Image-guided surgery using fluorescence: road to clinical translation of novel probes
Author(s): Pim J. Bongers; Leonora S. F. Boogerd; Henricus J. M. Handgraaf; Charlotte E. S. Hoogstins; Cornelis J. H. van de Velde; Jacobus Burggraaf; Alexander L. Vahrmeijer
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Paper Abstract

Fluorescence imaging using non-targeted fluorescent agents has been extensively studied during the last decade. Although proven feasible, tumor-specific imaging can be dramatically enhanced using tumor-specific fluorescent contrast agents. Clinical translation of these agents is challenging and hurdles have to be overcome. In this overview paper we recapitulate the key regulations for first-in-human studies with fluorescent agents, provide insight in different strategies for fast clinical translation and discuss how clinical introduction of the first fluorescent targeted agents was achieved.

Paper Details

Date Published: 4 March 2016
PDF: 7 pages
Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960Z (4 March 2016); doi: 10.1117/12.2224857
Show Author Affiliations
Pim J. Bongers, Leiden Univ. Medical Ctr. (Netherlands)
Leonora S. F. Boogerd, Leiden Univ. Medical Ctr. (Netherlands)
Henricus J. M. Handgraaf, Leiden Univ. Medical Ctr. (Netherlands)
Charlotte E. S. Hoogstins, Leiden Univ. Medical Ctr. (Netherlands)
Cornelis J. H. van de Velde, Leiden Univ. Medical Ctr. (Netherlands)
Jacobus Burggraaf, Ctr. for Human Drug Research (Netherlands)
Alexander L. Vahrmeijer, Leiden Univ. Medical Ctr. (Netherlands)


Published in SPIE Proceedings Vol. 9696:
Molecular-Guided Surgery: Molecules, Devices, and Applications II
Brian W. Pogue; Sylvain Gioux, Editor(s)

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