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Proceedings Paper

Si nanoparticles as sensitizers for radio frequency-induced cancer hyperthermia
Author(s): A. V. Kabashin; K. P. Tamarov; Yu. V. Ryabchikov; L. A. Osminkina; S. V. Zinovyev; J. V. Kargina; M. B. Gongalsky; A. Al-Kattan; V. G. Yakunin; M. L. Sentis; A. V. Ivanov; V. N. Nikiforov; A. P. Kanavin; I. N. Zavestovskaya; V. Yu. Timoshenko
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Paper Abstract

We review our recently obtained data on the employment of Si nanoparticles as sensitizers of radiofrequency (RF) - induced hyperthermia for mild cancer therapy tasks. Such an approach makes possible the heating of aqueous suspensions of Si nanoparticles by tens of degrees Celsius under relatively low intensities (1–5 W/cm2) of 27 MHz RF radiation. The heating effect is demonstrated for nanoparticles synthesized by laser ablation in water and mechanical grinding of porous silicon, while laser-ablated nanoparticles demonstrate a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations. The observed RF heating effect can be explained in the frame of a model considering the polarization of Si NPs and electrolyte in the external oscillating electromagnetic field and the corresponding release of heat by electric currents around the nanoparticles. Our tests evidence relative safety of Si nanostructures and their efficient dissolution in physiological solutions, suggesting potential clearance of nanoparticles from a living organism without any side effects. Profiting from Si nanoparticle-based heating, we finally demonstrate an efficient treatment of Lewis Lung carcinoma in vivo. The obtained data promise a breakthrough in the development of mild, non-invasive methods for cancer therapy.

Paper Details

Date Published: 9 March 2016
PDF: 10 pages
Proc. SPIE 9737, Synthesis and Photonics of Nanoscale Materials XIII, 97370A (9 March 2016); doi: 10.1117/12.2222814
Show Author Affiliations
A. V. Kabashin, Lab de. Lasers, Plasmas et Procédés Photoniques, Aix-Marseille Univ., CNRS (France)
K. P. Tamarov, Lomonosov Moscow State Univ. (Russian Federation)
Yu. V. Ryabchikov, Lab. de Lasers, Plasmas et Procédés Photoniques, Aix-Marseille Univ., CNRS (France)
P.N. Lebedev Physical Institute (Russian Federation)
L. A. Osminkina, Lomonosov Moscow State Univ. (Russian Federation)
National Research Nuclear Univ. "MEPhI" (Russian Federation)
S. V. Zinovyev, N.N. Blokhin Russian Cancer Research Ctr. (Russian Federation)
J. V. Kargina, Lomonosov Moscow State Univ. (Russian Federation)
M. B. Gongalsky, Lomonosov Moscow State Univ. (Russian Federation)
National Research Nuclear Univ. "MEPhI" (Russian Federation)
A. Al-Kattan, Lab. de Lasers, Plasmas et Procédés Photoniques, Aix-Marseille Univ., CNRS (France)
V. G. Yakunin, Lomonosov Moscow State Univ. (Russian Federation)
M. L. Sentis, Lab. de Lasers, Plasmas et Procédés Photoniques, Aix-Marseille Univ., CNRS (France)
A. V. Ivanov, N.N. Blokhin Russian Cancer Research Ctr. (Russian Federation)
V. N. Nikiforov, Lomonosov Moscow State Univ. (Russian Federation)
A. P. Kanavin, P.N. Lebedev Physical Institute (Russian Federation)
National Nuclear Research Univ. "MEPhI" (Russian Federation)
I. N. Zavestovskaya, P.N. Lebedev Physical Institute (Russian Federation)
National Nuclear Research Univ. "MEPhI" (Russian Federation)
V. Yu. Timoshenko, Lomonosov Moscow State Univ. (Russian Federation)
P.N. Lebedev Physical Institute (Russian Federation)
National Research Nuclear Univ. "MEPhI" (Russian Federation)


Published in SPIE Proceedings Vol. 9737:
Synthesis and Photonics of Nanoscale Materials XIII
Andrei V. Kabashin; David B. Geohegan; Jan J. Dubowski, Editor(s)

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